Enpp6 Gene Summary [Rat]
Predicted to enable glycerophosphocholine cholinephosphodiesterase activity and glycerophosphodiester phosphodiesterase activity. Predicted to be involved in choline metabolic process and lipid metabolic process. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. Orthologous to human ENPP6 (ectonucleotide pyrophosphatase/phosphodiesterase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Enpp6 |
| Official Name | ectonucleotide pyrophosphatase/phosphodiesterase 6 [Source:RGD Symbol;Acc:1311645] |
| Ensembl ID | ENSRNOG00000009660 |
| Bio databases IDs | |
| Aliases | ectonucleotide pyrophosphatase/phosphodiesterase 6 |
| Synonyms | 4833421B01RIK, B830047L21RIK, D8Ertd514e, ectonucleotide pyrophosphatase/phosphodiesterase 6, GPC-Cpde, LOC100911549, NPP6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Enpp6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alkaline phosphatases and sulfatases
- Type I phosphodiesterase / nucleotide pyrophosphatase
- enzyme
- protein binding
- glycerophosphocholine cholinephosphodiesterase
- glycerophosphodiester phosphodiesterase
- phosphoric diester hydrolase
Pathways
Biological processes and signaling networks where the Enpp6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- renal clear cell cancer
- COVID-19
- psychosis
- squamous-cell carcinoma
- squamous cell cancer
- insomnia
- Kawasaki disease
regulates
- lipid
- phosphorylcholine
- lysophosphatidylcholine
- choline
- sn-glycero-3-phosphocholine
- glycerophospholipid
- sphingosylphosphocholine
- 4-nitrophenylphosphorylcholine
- monoacylglycerol
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Enpp6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycerophospholipid catabolic process
- lipid metabolic process
- choline metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- phosphoric diester hydrolase activity
- glycerophosphodiester phosphodiesterase activity
- glycerophosphocholine cholinephosphodiesterase activity