Kcnn4 Gene Summary [Rat]
Enables intermediate conductance calcium-activated potassium channel activity and inward rectifier potassium channel activity. Involved in several processes, including hepatocyte apoptotic process; regulation of cytokine production; and regulation of systemic arterial blood pressure. Located in apical plasma membrane; basolateral plasma membrane; and neuronal cell body. Used to study hypertension; middle cerebral artery infarction; and temporal lobe epilepsy. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in angiosarcoma; cerebral infarction; dehydrated hereditary stomatocytosis 2; and myocardial infarction. Orthologous to human KCNN4 (potassium calcium-activated channel subfamily N member 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kcnn4 |
| Official Name | potassium calcium-activated channel subfamily N member 4 [Source:RGD Symbol;Acc:621476] |
| Ensembl ID | ENSRNOG00000019440 |
| Bio databases IDs | |
| Aliases | potassium calcium-activated channel subfamily N member 4 |
| Synonyms | DHS2, Gardos channel, hIK1, hIKCa1, hKCa4, hSK4, IK, IK1, IKCA1, KCa3.1, KCA4, mIK1, mIKCa1, mKCa4, potassium calcium-activated channel subfamily N member 4, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, rIK1, rKCNN4c, rSK4, SK4, SKCas, SMIK |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kcnn4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Calcium-activated SK potassium channel
- potassium channel
- inward rectifier potassium channel
- calmodulin binding
- protein phosphatase binding
- transmembrane domain
- calmodulin binding domain
- calcium-activated potassium channel
- protein homodimerization
- cytosolic tail domain
- protein binding
- ion channel
Pathways
Biological processes and signaling networks where the Kcnn4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- HIV infection
- edema
- tinea cruris
- bacterial vaginitis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- dehydrated hereditary stomatocytosis type 2
- epidermal hyperplasia
regulated by
- tetradecanoylphorbol acetate
- D-glucose
- adenosine triphosphate
- Ca2+
- calmodulin
- oxygen
- adenosine
- charybdotoxin
- SOS
- [3,5-bis[(3-fluoro-4-hydroxy-benzoyl)oxymethyl]phenyl]methyl 3-fluoro-4-hydroxy-benzoate
role in cell
- apoptosis
- chemotaxis
- proliferation
- migration
- expression in
- formation
- activation
- transmembrane potential
- function
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- cellular membrane
- Nucleus
- vesicles
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- membrane ruffles
- apical membrane
- basolateral membrane
- neurites
- intercalated disks
- sarcolemma
- cell membrane leading edge
- perikaryon
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kcnn4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- potassium ion transmembrane transport
- defense response
- cell volume homeostasis
- immune system process
- potassium ion transport
- positive regulation of T cell receptor signaling pathway
- saliva secretion
- phospholipid translocation
- calcium ion transport
- positive regulation of protein secretion
- establishment of localization in cell
- stabilization of membrane potential
Cellular Component
Where in the cell the gene product is active
- voltage-gated potassium channel complex
- vesicle
- cytosol
- neuronal cell body
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium-activated potassium channel activity
- calmodulin binding
- protein binding
- protein phosphatase binding
- small conductance calcium-activated potassium channel activity
- potassium channel activity
- Intermediate conductance calcium-activated potassium channel activity