Smarcd3 Gene Summary [Rat]
Enables chromatin binding activity. Involved in positive regulation of G2/M transition of mitotic cell cycle and positive regulation of smooth muscle cell differentiation. Predicted to be located in chromatin; cytoplasm; and nucleoplasm. Predicted to be part of SWI/SNF complex; nBAF complex; and npBAF complex. Predicted to be active in nucleus. Orthologous to human SMARCD3 (SWI/SNF related BAF chromatin remodeling complex subunit D3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smarcd3 |
| Official Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 [Source:RGD Symbol;Acc:1311869] |
| Ensembl ID | ENSRNOG00000010077 |
| Bio databases IDs | |
| Aliases | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 |
| Synonyms | 1500001J14Rik, 2210409C08RIK, BAF60C, CRACD3, Rsc6p, SWI/SNF related BAF chromatin remodeling complex subunit D3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smarcd3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SWIB/MDM2 domain
- transcription regulator
- ligand-dependent nuclear receptor interactor
- LXXLL motif
- transcription co-activator
- transcription factor binding
- chromatin binding
- protein binding
- receptor binding
- SWIB/MDM2 domain family
- SWI complex, BAF60b domains
Pathways
Biological processes and signaling networks where the Smarcd3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin resistance
- prostate cancer
- allergic rhinitis
- plasma cell myeloma
- impaired glucose tolerance
- bleeding
- androgenic alopecia
- ventricular septal defect
- prostatic intraepithelial neoplasm
- prostatic intraepithelial neoplasia
role in cell
- expression in
- survival
- activation in
- quantity
- proliferation
- abnormal morphology
- differentiation
- disassembly
- accumulation in
- non-homologous end joining in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smarcd3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitotic metaphase/anaphase transition
- nervous system development
- positive regulation of neuroblast proliferation
- positive regulation of cell differentiation
- positive regulation of myoblast differentiation
- regulation of nucleotide-excision repair
- nucleosome disassembly
- regulation of transcription from RNA polymerase II promoter
- secondary heart field specification
- chromatin remodeling
- positive regulation of transcription, DNA-dependent
- cardiac right ventricle formation
- neural retina development
- positive regulation of smooth muscle cell differentiation
- positive regulation of T cell differentiation
- muscle cell differentiation
- regulation of G1/S transition of mitotic cell cycle
- positive regulation of double-strand break repair
- regulation of G0 to G1 transition
- positive regulation of G2/M transition of mitotic cell cycle
Cellular Component
Where in the cell the gene product is active
- nucleus
- SWI/SNF complex
- npBAF complex
- nBAF complex
- brahma complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor binding
- ligand-dependent nuclear receptor binding
- transcription cofactor activity
- transcription coactivator activity
- chromatin binding
- receptor binding