Prss8 Gene Summary [Rat]
Predicted to enable sodium channel regulator activity. Involved in several processes, including positive regulation of sodium ion transmembrane transport; response to mineralocorticoid; and response to peptide hormone. Located in extracellular space. Used to study alopecia. Orthologous to human PRSS8 (serine protease 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prss8 |
| Official Name | serine protease 8 [Source:RGD Symbol;Acc:619973] |
| Ensembl ID | ENSRNOG00000019616 |
| Bio databases IDs | |
| Aliases | serine protease 8 |
| Synonyms | 2410039E18Rik, CAP1, fr, mCAP1, PROSTASIN, serine protease 8, serine protease 8 (prostasin), Serine protease stubble |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Prss8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
- Domain of unknown function (DUF1986)
- sodium channel regulator
- protein binding
Pathways
Biological processes and signaling networks where the Prss8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- ulceration
- hyperplasia
- ichthyosis
- metastasis
- acanthosis
- advanced cancer
- cancer
- uterine serous papillary cancer
- colitis
role in cell
- proliferation
- activation in
- migration
- cell death
- differentiation
- growth
- invasion by
- colony formation by
- sphere formation by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- nuclear fraction
- cellular membrane
- Plasma Membrane
- cytosol
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Prss8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- positive regulation of sodium ion transport
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type peptidase activity
- serine-type endopeptidase activity