C2

Predicted to enable serine-type endopeptidase activity. Involved in complement activation; response to lipopolysaccharide; and response to thyroid hormone. Located in extracellular space. Biomarker of polycystic kidney disease and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); complement deficiency (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to several human genes including C2 (complement C2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the C2 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat C2 gene, providing context for its role in the cell.