Glrx Gene Summary [Rat]
Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of secretion by cell; and regulation of signal transduction. Located in dendrite and neuronal cell body. Biomarker of obesity and transient cerebral ischemia. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Glrx |
| Official Name | glutaredoxin [Source:RGD Symbol;Acc:70951] |
| Ensembl ID | ENSRNOG00000012183 |
| Bio databases IDs | |
| Aliases | glutaredoxin |
| Synonyms | D13Wsu156e, GLRX1, glutaredoxin, GRX, GRX1, TTase |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Glrx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glutaredoxin-family domain
- glutathione dehydrogenase (ascorbate)
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- protein-disulfide reductase (glutathione)
- sodium channel regulator
- enzyme
- protein binding
- glutathione disulfide oxidoreductase
Pathways
Biological processes and signaling networks where the Glrx gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastatic colorectal cancer
- peripheral arterial disease
- Alzheimer disease
- septic shock
- testicular germ cell tumor
- germ cell neoplasia
- papillomatosis
- schizophrenia
- dermatomyositis
- idiopathic scoliosis
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- formation in
- survival
- cell death
- production in
- accumulation in
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Glrx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of membrane potential
- nucleobase-containing small molecule interconversion
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- glutathione disulfide oxidoreductase activity
- sodium channel regulator activity
- protein binding