Pik3c2a Gene Summary [Rat]
Predicted to enable clathrin binding activity and phosphatidylinositol kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pik3c2a |
| Official Name | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [Source:RGD Symbol;Acc:1310389] |
| Ensembl ID | ENSRNOG00000020479 |
| Bio databases IDs | |
| Aliases | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha |
| Synonyms | CPK, Cpk-m, OCSKD, p170 Pi3-kinase, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha, phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 α, phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 α, PI3KC2, PI3-K-C2A, PI3-K-C2(ALPHA), PI3K-C2-alpha, PI3-K-C2(α), PI3K-C2-α |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pik3c2a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- activation domain
- clathrin binding domain
- Phosphatidylinositol 3- and 4-kinase
- phosphatidylinositol-4,5-bisphosphate 3-kinase
- clathrin binding
- PI3-kinase family, ras-binding domain
- PI3Ka
- kinase
- phosphatidylinositol 3-kinase
- phosphatidylinositol-4-phosphate 3-kinase
- Phosphoinositide 3-kinase, catalytic domain
- Protein Kinases, catalytic domain
- The Phox Homology domain, a phosphoinositide binding module
- Protein kinase C conserved region 2 (CalB)
- PX domain
- C2 domain
Pathways
Biological processes and signaling networks where the Pik3c2a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Cardiomyocyte Signaling Pathway
- Apelin Pancreas Signaling Pathway
- Clathrin-mediated Endocytosis Signaling
- CNTF Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- EGF Signaling
- ErbB Signaling
- ErbB4 Signaling
- Glucocorticoid Receptor Signaling
- Growth Hormone Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- IL-9 Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- MSP-RON Signaling Pathway
- Neurotrophin/TRK Signaling
- NGF Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- p53 Signaling
- PDGF Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Th1 Pathway
- Th2 Pathway
- Thyroid Cancer Signaling
- VEGF Family Ligand-Receptor Interactions
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- renal clear cell adenocarcinoma
- insomnia
- chronic stable angina
- bipolar disorder
- oculoskeletodental syndrome
- schizophrenia
- arterial occlusive disease
- disease-free survival
- renal clear cell cancer
- acute coronary syndrome
role in cell
- growth
- phosphorylation in
- expression in
- migration
- activation in
- proliferation
- survival
- stabilization in
- organization
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- plasma membrane/trans-Golgi network fraction
- low-density microsomal fraction
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- cytosol
- trans Golgi network
- nucleoplasm
- nuclear speckles
- clathrin-coated pits
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pik3c2a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane organization
- insulin receptor signaling pathway
- epidermal growth factor receptor signaling pathway
- phosphatidylinositol-3-phosphate biosynthetic process
- platelet-derived growth factor receptor signaling pathway
- phosphatidylinositol biosynthetic process
- endocytosis
- positive regulation of cell migration involved in sprouting angiogenesis
- exocytosis
- positive regulation of autophagy
- protein kinase B signaling cascade
- clathrin coat assembly
- vascular smooth muscle contraction
- phosphatidylinositol-mediated signaling
- cell migration
Cellular Component
Where in the cell the gene product is active
- phosphatidylinositol 3-kinase complex
- trans-Golgi network
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
- membrane
- vesicle
- cytosol
- clathrin-coated vesicle
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- phosphatidylinositol binding
- clathrin binding
- phosphatidylinositol-4,5-bisphosphate 3-kinase activity
- 1-phosphatidylinositol-4-phosphate 3-kinase activity
- 1-phosphatidylinositol-3-kinase activity