Rap1gap Gene Summary [Rat]
Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in cellular response to glial cell derived neurotrophic factor; negative regulation of neuron differentiation; and negative regulation of thyroid gland epithelial cell proliferation. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Orthologous to human RAP1GAP (RAP1 GTPase activating protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rap1gap |
| Official Name | Rap1 GTPase-activating protein [Source:RGD Symbol;Acc:1309908] |
| Ensembl ID | ENSRNOG00000013825 |
| Bio databases IDs | |
| Aliases | Rap1 GTPase-activating protein |
| Synonyms | 1300019I11Rik, 2310004O14Rik, ARPP-90, Gap, KIAA0474, RAP1B.GAP, RAP1GA1, RAP1GAP1, RAP1GAPII, RAP1 GTPase activating protein, RAPGAP, RAPGAPII |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rap1gap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rap/ran-GAP
- G-protein regulatory motif
- GoLoco motif
- enzyme binding
- protein homodimerization
- GTPase activator
- protein binding
Pathways
Biological processes and signaling networks where the Rap1gap gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- idiopathic inflammatory myopathy
- Huntington disease
- renal cell cancer
- colorectal carcinoma
- colorectal carcinomagenesis
- major depression
- papillary thyroid carcinoma
- papillary thyroid cancer
- head and neck squamous cell carcinoma
role in cell
- proliferation
- expression in
- differentiation
- formation in
- cell death
- adhesion
- signaling in
- growth
- number
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- cytosol
- Golgi membrane
- early endosomes
- perikaryon
- axons
- dendrites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rap1gap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- signal transduction
- regulation of GTPase activity
- negative regulation of neuron differentiation
- adaptive immune response
- positive regulation of GTPase activity
Cellular Component
Where in the cell the gene product is active
- dendrite
- early endosome
- cytoplasm
- membrane
- cytosol
- Golgi membrane
- neuronal cell body
- axon
Molecular Function
What the gene product does at the molecular level
- protein homodimerization activity
- protein binding
- GTPase activity
- GTPase activator activity
- small GTPase binding