Ahrr Gene Summary [Rat]
Predicted to enable nuclear receptor activity and transcription cis-regulatory region binding activity. Involved in nitric oxide metabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of aryl hydrocarbon receptor complex. Predicted to be active in nucleus. Biomarker of hypertension. Orthologous to human AHRR (aryl hydrocarbon receptor repressor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ahrr |
| Official Name | aryl-hydrocarbon receptor repressor [Source:RGD Symbol;Acc:1559857] |
| Ensembl ID | ENSRNOG00000014721 |
| Bio databases IDs | |
| Aliases | aryl-hydrocarbon receptor repressor |
| Synonyms | AHH, AHHR, aryl-hydrocarbon receptor repressor, bHLHe77, mKIAA1234 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ahrr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- PAS
- basic Helix Loop Helix (bHLH) domain superfamily
- helix loop helix domain
- protein binding
- Helix-loop-helix DNA-binding domain
- basic helix loop helix/Per Arnt Sim domain
Pathways
Biological processes and signaling networks where the Ahrr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- endometriosis
- idiopathic scoliosis
- androgenic alopecia
- hearing loss
- cystic fibrosis
role in cell
- transactivation in
- repression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ahrr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- xenobiotic metabolic process
- intracellular receptor mediated signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- aryl hydrocarbon receptor complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
- transcription regulatory region sequence-specific DNA binding
- protein dimerization activity
- sequence-specific DNA binding RNA polymerase II transcription factor activity