Emilin2 Gene Summary [Rat]
Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of blood coagulation; and positive regulation of platelet aggregation. Predicted to be located in extracellular region. Orthologous to human EMILIN2 (elastin microfibril interfacer 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Emilin2 |
| Official Name | elastin microfibril interfacer 2 [Source:RGD Symbol;Acc:1305343] |
| Ensembl ID | ENSRNOG00000014837 |
| Bio databases IDs | |
| Aliases | elastin microfibril interfacer 2 |
| Synonyms | elastin microfibril interfacer 2, FOAP-10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Emilin2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPEC
- Collagen triple helix repeat (20 copies)
- EMI domain
- protein binding
- Apolipoprotein A1/A4/E domain
- globular head domain
- SF-assemblin/beta giardin
- C1q domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- colorectal cancer
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
role in cell
- cell death
- apoptosis
- survival
- growth
- migration
- proliferation
- clonogenicity
- aggregation
- dissemination
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cell borders
- extracellular matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Emilin2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion mediated by integrin
- positive regulation of blood coagulation
- positive regulation of apoptotic process
- regulation of blood pressure
- negative regulation of cell migration
- positive regulation of angiogenesis
- regulation of cell proliferation
- positive regulation of defense response to bacterium
Cellular Component
Where in the cell the gene product is active
- collagen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- extracellular matrix constituent conferring elasticity