Klkb1 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Involved in liver regeneration. Located in extracellular space. Used to study inflammatory bowel disease. Biomarker of liver cirrhosis. Human ortholog(s) of this gene implicated in lupus nephritis and systemic lupus erythematosus. Orthologous to human KLKB1 (kallikrein B1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klkb1 |
| Official Name | kallikrein B1 [Source:RGD Symbol;Acc:67382] |
| Ensembl ID | ENSRNOG00000014118 |
| Bio databases IDs | |
| Aliases | kallikrein B1 |
| Synonyms | APS, Kal-3, kallikrein B1, kallikrein B, plasma 1, Kalp1, KALP15, Kininogenin, KLK3, PK, PKK, PKKD, PPK, PREKALLIKREIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klkb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAN_APPLE
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- apple domain
- plasma kallikrein
- PAN domain
- protein binding
Pathways
Biological processes and signaling networks where the Klkb1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- epithelial cancer
- coronary artery disease
- prekallikrein deficiency
- hereditary angioedema type II
- hereditary angioedema
- edema
- venous thromboembolism
- postoperative hemorrhage
- perioperative hemorrhage
role in cell
- synthesis in
- activation in
- activation
- number
- aggregation
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klkb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- zymogen activation
- positive regulation of fibrinolysis
- plasminogen activation
- proteolysis
- blood coagulation
- fibrinolysis
- Factor XII activation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity