F11 Gene Summary [Rat]
Enables serine-type aminopeptidase activity. Predicted to be involved in blood coagulation; plasminogen activation; and positive regulation of fibrinolysis. Predicted to act upstream of or within regulation of blood coagulation. Located in extracellular space. Human ortholog(s) of this gene implicated in factor XI deficiency and thrombosis. Orthologous to human F11 (coagulation factor XI). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F11 |
| Official Name | coagulation factor XI [Source:RGD Symbol;Acc:1309364] |
| Ensembl ID | ENSRNOG00000013684 |
| Bio databases IDs | |
| Aliases | coagulation factor XI |
| Synonyms | 1600027G01Rik, Cf11, coagulation factor XI, factor XI, FXI, LRRGT00086, PLATELET FACTOR XI, PTA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAN_APPLE
- Trypsin-like serine protease
- Tryp_SPc
- catalytic domain
- peptidase
- coagulation factor XIa
- protein binding
- identical protein binding
- trypsin
- serine endopeptidase
- serine-type peptidase
- aminopeptidase
- apple 4 dimerization domain
- apple domain
- PAN domain
- exopeptidase
Pathways
Biological processes and signaling networks where the F11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- fibrosis
- epithelial cancer
- plasma factor XI deficiency
- atrial fibrillation
- factor X deficiency
- transient ischemic attack
- ischemic stroke
- ST-elevation myocardial infarction
- myocardial necrosis
role in cell
- binding
- quantity
- number
- aggregation
- abnormal morphology
- deposition
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of fibrinolysis
- plasminogen activation
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- serine-type endopeptidase activity
- heparin binding
- serine-type aminopeptidase activity