NQO2
NQO2 Gene Summary
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Details
| Type | Protein Coding |
| Official Symbol | NQO2 |
| Official Name | N-ribosyldihydronicotinamide:quinone reductase 2 [Source:HGNC Symbol;Acc:HGNC:7856] |
| Ensembl ID | ENSG00000124588 |
| Bio databases IDs | |
| Aliases | N-ribosyldihydronicotinamide:quinone reductase 2 |
| Synonyms | DHQV,DIA6,LOC285771,NMO2,NMOR2,N-ribosyldihydronicotinamide:quinone dehydrogenase 2,N-ribosyldihydronicotinamide quinone reductase 2,Ox2,QR2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding
- electron carrier
- binding protein
- zinc ion binding
- oxidoreductase
- dihydronicotinamide riboside quinone reductase
- protein homodimerization
- enzyme
- protein binding
- nitrogenous compound oxidoreductase
- Flavodoxin-like fold
- NADPH-dependent FMN reductase
Pathways
Biological processes and signaling networks where the NQO2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- CEBPB
- LRRC7
- NCL
- caricotamide
- HNRNPL
- GORASP2
- TRIM67
- RHOB
- MOV10
- DDIT4L
disease
- skin neoplasia
- breast cancer
- liver neoplasia
- cancer
- cleft lip
- thrombocytosis
- neoplasia
- Parkinson disease
- myeloid hyperplasia
- Alzheimer disease
regulated by
- mifepristone
- GLI1
- TNF
- quercetin
- imatinib
- benzo(a)pyrene
- nicotinate D-ribonucleoside
- arsenic trioxide
- metribolone
- prednisolone
regulates
- TNF
- p38 MAPK
- PTGS2
- IL1B
- ERK1/2
- IL6
- MAPK8
- NOS2
- NFkB (complex)
- RELA
role in cell
- expression in
- quantity
- activation in
- production in
- number
- proliferation
- apoptosis
- homing
- transmembrane potential
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the NQO2 gene, providing context for its role in the cell.
CELLULAR COMPONENT
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- FAD binding
- chloride ion binding
- zinc ion binding
- protein binding
- dihydronicotinamide riboside quinone reductase activity
- protein homodimerization activity
- NAD(P)H dehydrogenase (quinone) activity
- oxidoreductase activity
- electron carrier activity
- oxidoreductase activity, acting on other nitrogenous compounds as donors