Mt3 Gene Summary [Rat]
Enables copper ion binding activity and zinc ion binding activity. Involved in negative regulation of hydrogen peroxide catabolic process. Located in several cellular components, including astrocyte end-foot; mitochondrial outer membrane; and synaptic vesicle. Used to study motor neuron disease. Biomarker of borna disease; hypothyroidism; median neuropathy; middle cerebral artery infarction; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human MT3 (metallothionein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mt3 |
| Official Name | metallothionein 3 [Source:RGD Symbol;Acc:621252] |
| Ensembl ID | ENSRNOG00000018958 |
| Bio databases IDs | |
| Aliases | metallothionein 3 |
| Synonyms | GIF, GIFB, GRIF, Metallothionein 3, ZnMT3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mt3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- copper ion binding
- zinc ion binding
- Metallothionein
- metal ion binding
- protein binding
- cadmium ion binding
Pathways
Biological processes and signaling networks where the Mt3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- diabetic nephropathy
- tumorigenesis
- psychosis
- limbic seizure
- osteoarthritis
- seizures
role in cell
- activation in
- expression in
- apoptosis
- proliferation
- necrosis
- cell death
- growth
- chemorepulsion
- inhibition
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- intracellular space
- perinuclear region
- ribosome
- Nucleus
- microtubules
- cytosol
- mitochondrial outer membrane
- dendritic spines
- synaptic vesicles
- perikaryon
- axons
- astrocyte projections
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mt3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of response to food
- cellular zinc ion homeostasis
- cellular response to copper ion
- negative regulation of neuron apoptotic process
- response to hypoxia
- cellular response to zinc ion
- negative regulation of neuron projection development
- positive regulation of transcription, DNA-dependent
- negative regulation of cell growth
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- cellular response to cadmium ion
- positive regulation of oxygen metabolic process
- cellular response to hypoxia
- cellular cation homeostasis
- activation of protein kinase B activity
- detoxification of copper ion
- leptin-mediated signaling pathway
- negative regulation of hydrogen peroxide catabolic process
- energy reserve metabolic process
- negative regulation of oxidoreductase activity
- negative regulation of axon extension
- zinc ion transport
- positive regulation of gene expression
- removal of superoxide radicals
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- cellular response to oxidative stress
- protein stabilization
- cellular response to reactive oxygen species
Cellular Component
Where in the cell the gene product is active
- synaptic vesicle
- ribosome
- mitochondrial outer membrane
- microtubule
- nucleus
- extracellular space
- perinuclear region of cytoplasm
- cytoplasm
- dendritic spine
- cytosol
- inclusion body
- axon
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding
- antioxidant activity
- copper ion binding
- metal ion binding
- protein kinase activator activity
- cadmium ion binding