Ell Gene Summary [Rat]
Predicted to enable cis-regulatory region sequence-specific DNA binding activity and phosphatase binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and snRNA transcription. Predicted to act upstream of or within in utero embryonic development. Predicted to be located in cytosol; euchromatin; and nuclear body. Predicted to be part of transcription elongation factor complex. Orthologous to human ELL (elongation factor for RNA polymerase II). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ell |
| Official Name | elongation factor for RNA polymerase II [Source:RGD Symbol;Acc:1311121] |
| Ensembl ID | ENSRNOG00000019824 |
| Bio databases IDs | |
| Aliases | elongation factor for RNA polymerase II |
| Synonyms | C19orf17, DKFZP434I1916, ELL1, elongation factor for RNA polymerase II, elongation factor RNA polymerase II, LOC100911828, MEN, PPP1R68 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ell often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II elongation factor ELL
- lysine rich domain
- transcription regulator
- occludin-like domain
- EAF1 binding domain
- elongation domain
- protein binding
- Occludin homology domain
- phosphatase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- heart disease
- fasciitis
- coronary artery disease
- metabolic syndrome X
- breast carcinoma
- Dupuytren contracture
- estrogen receptor-negative breast cancer
- allergy
role in cell
- apoptosis
- growth
- proliferation
- expression in
- quantity
- immortalization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear bodies
- nuclear speckles
- Cajal bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ell gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription elongation from RNA polymerase II promoter
- in utero embryonic development
- snRNA transcription from RNA polymerase II promoter
- snRNA transcription from RNA polymerase III promoter
- positive regulation of transcription from RNA polymerase III promoter
- positive regulation of transcription elongation, DNA-dependent
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- histone locus body
- euchromatin
- nuclear body
- transcription elongation factor complex
- nuclear speck
- Cajal body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein binding
- core promoter proximal region sequence-specific DNA binding