Acsl6 Gene Summary [Rat]
Enables arachidonate-CoA ligase activity and protein homodimerization activity. Involved in several processes, including cellular response to insulin stimulus; lipid biosynthetic process; and positive regulation of long-chain fatty acid import across plasma membrane. Predicted to be located in endoplasmic reticulum membrane; mitochondrial outer membrane; and peroxisomal membrane. Predicted to be active in endoplasmic reticulum and membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia and leukemia. Orthologous to human ACSL6 (acyl-CoA synthetase long chain family member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acsl6 |
| Official Name | acyl-CoA synthetase long-chain family member 6 [Source:RGD Symbol;Acc:69403] |
| Ensembl ID | ENSRNOG00000026745 |
| Bio databases IDs | |
| Aliases | acyl-CoA synthetase long-chain family member 6 |
| Synonyms | A330035H04Rik, ACS2, acyl-CoA synthetase long-chain family member 6, AW050338, DKFZp547D104, FACL6, LACS, LACS2, LACS5, LACS 6, Lacsl, long CHAIN ACYL COA SYNTHETASE6, mKIAA0837 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acsl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- long-chain-fatty-acid-CoA ligase
- arachidonate-CoA ligase
- AMP-binding enzyme
- protein homodimerization
- Adenylate forming domain, Class I superfamily
- O-succinylbenzoate-CoA ligase
- enzyme binding
- enzyme
- protein binding
- amino acid adenylation domain
Pathways
Biological processes and signaling networks where the Acsl6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- colorectal cancer
- Alzheimer disease
- osteoarthritis
- glioblastoma
- critical COVID-19
- glioblastoma cancer
- atopic dermatitis
role in cell
- expression in
- proliferation
- length
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- microsome
- mitochondrial outer membrane
- peroxisome membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acsl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- neuroblast proliferation
- long-chain fatty acid metabolic process
- long-chain fatty-acyl-CoA biosynthetic process
- very long-chain fatty acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- peroxisomal membrane
- membrane
- endoplasmic reticulum
- mitochondrial outer membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- arachidonate-CoA ligase activity
- long-chain fatty acid-CoA ligase activity