Etv4 Gene Summary [Rat]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell differentiation; positive regulation of keratinocyte differentiation; and regulation of gene expression. Predicted to act upstream of or within several processes, including branching involved in mammary gland duct morphogenesis; motor neuron axon guidance; and negative regulation of mammary gland epithelial cell proliferation. Predicted to be located in chromosome and nucleolus. Predicted to be active in nucleus. Orthologous to human ETV4 (ETS variant transcription factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Etv4 |
| Official Name | ETS variant transcription factor 4 [Source:RGD Symbol;Acc:1306524] |
| Ensembl ID | ENSRNOG00000020792 |
| Bio databases IDs | |
| Aliases | ETS variant transcription factor 4 |
| Synonyms | E1A-F, ets variant 4, ETS variant transcription factor 4, PEA3, PEAS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Etv4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- activation domain
- transcription regulator
- DNA binding domain
- nucleic acid binding
- protein binding
- glutamine-rich domain
- sequence-specific DNA binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- Ets-domain
- PEA3 subfamily ETS-domain transcription factor N terminal domain
Pathways
Biological processes and signaling networks where the Etv4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- Wilms tumor
- Wilms tumorigenesis
- organismal death
- lung adenocarcinoma formation
- epithelial cancer
- Huntington disease
- hepatocellular carcinoma
- liver cancer
role in cell
- proliferation
- expression in
- migration
- production in
- glycolysis in
- differentiation
- invasion
- invasion by
- branching
- synthesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- intracellular space
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Etv4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of keratinocyte differentiation
- cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity