Il2rb Gene Summary [Rat]
Enables interleukin-2 binding activity and interleukin-2 receptor activity. Involved in cytokine-mediated signaling pathway. Located in cell surface. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 63; myasthenia gravis; and visceral leishmaniasis. Orthologous to human IL2RB (interleukin 2 receptor subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il2rb |
| Official Name | interleukin 2 receptor subunit beta [Source:RGD Symbol;Acc:2896] |
| Ensembl ID | ENSRNOG00000048636 |
| Bio databases IDs | |
| Aliases | interleukin 2 receptor subunit beta |
| Synonyms | CD122, IL15RB, IL-15R beta, IL-15R β, Il-2/15Rbeta, IL2RBC, Il-2Rbeta, Il2r β, Il2r β C, IMD63, interleukin 2 receptor, beta chain, interleukin 2 receptor subunit beta, interleukin 2 receptor subunit β, interleukin 2 receptor, β chain, p70, P70-75 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il2rb often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- protein binding
- Fibronectin type 3 domain
- acidic domain
- interleukin-2 receptor
- Stat5 binding domain
- interleukin-2 binding
- WSXWS motif
- Shc binding site
- serine-rich region
- cytoplasmic domain
- signal sequence domain
- FN3
- interleukin-15 receptor
- transmembrane domain
- intracellular domain
- Interleukin-2 receptor subunit beta N-terminal domain 1
- cytosolic tail domain
- transmembrane receptor
- A domain
- coreceptor
Pathways
Biological processes and signaling networks where the Il2rb gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Glucocorticoid Receptor Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- IL-15 Signaling
- IL-2 Signaling
- Molecular Mechanisms of Cancer
- Natural Killer Cell Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- STAT3 Pathway
- Telomerase Signaling
- Th1 and Th2 Activation Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- refractory anemia with excess blasts
- chronic myelomonocytic leukemia
- refractory anemia with excess blasts in transformation
- bipolar disorder
- kidney disease
- mycosis fungoides
- Sézary syndrome
- renal clear cell adenocarcinoma
- cutaneous melanoma
- stage 2 neuroblastoma
role in cell
- growth
- proliferation
- production in
- activation in
- phosphorylation in
- apoptosis
- expression in
- number
- binding in
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- membrane fraction
- Cytoplasm
- cell surface
- cell borders
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- Golgi Apparatus
- Endoplasmic Reticulum
- cytosol
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il2rb gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- interleukin-2-mediated signaling pathway
- signal transduction
- cytokine-mediated signaling pathway
- negative regulation of apoptotic process
- immunoglobulin mediated immune response
- interleukin-15-mediated signaling pathway
- positive regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- endosome
- membrane
- external side of plasma membrane
- cytosol
- interleukin-2 receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- coreceptor activity
- interleukin-2 receptor activity
- protein binding
- interleukin-15 receptor activity
- cytokine receptor activity
- interleukin-2 binding