Acp1 Gene Summary [Rat]
Enables SH3 domain binding activity; acid phosphatase activity; and protein tyrosine phosphatase activity. Involved in chemical synaptic transmission. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and sarcolemma. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; conduct disorder; diabetes mellitus (multiple); diabetic retinopathy; and obesity. Orthologous to human ACP1 (acid phosphatase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Acp1 |
| Official Name | acid phosphatase 1 [Source:RGD Symbol;Acc:2020] |
| Ensembl ID | ENSRNOG00000005260 |
| Bio databases IDs | |
| Aliases | acid phosphatase 1 |
| Synonyms | 4632432E04Rik, acid phosphatase 1, acid phosphatase 1, soluble, HAAP, LMPTP, LMW-PTP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Acp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- acid phosphatase
- protein-tyrosine-phoshatase
- phosphatase
- Low molecular weight phosphatase family
- protein binding
- Low molecular weight phosphotyrosine protein phosphatase
- SH3-domain binding
Pathways
Biological processes and signaling networks where the Acp1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- Huntington disease
- chronic lymphocytic leukemia
- early onset hypertension
- osteonecrosis
role in cell
- growth
- activation in
- quantity
- phosphorylation in
- adhesion
- proliferation
- migration
- attachment
- motility
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- soluble fraction
- detergent-insoluble fractions
- Plasma Membrane
- cell-cell contacts
- cytosol
- cytoplasmic face of plasma membrane
- caveolae
- sarcolemma
- cytoskeletal fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Acp1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- sarcolemma
- cytosol
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- non-membrane spanning protein tyrosine phosphatase activity
- protein tyrosine phosphatase activity
- acid phosphatase activity