Nlrp14 Gene Summary [Rat]
Predicted to be involved in regulation of inflammatory response and spermatogenesis. Predicted to be part of canonical inflammasome complex. Predicted to be active in cytoplasm. Orthologous to human NLRP14 (NLR family pyrin domain containing 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nlrp14 |
| Official Name | NLR family, pyrin domain containing 14 [Source:RGD Symbol;Acc:1598218] |
| Ensembl ID | ENSRNOG00000023847 |
| Bio databases IDs | |
| Aliases | NLR family, pyrin domain containing 14 |
| Synonyms | 4921520L01Rik, CLR11.2, GC-LRR, NALP14, Nalp14l, Nalp-iota, Nalp-ι, NLR family pyrin domain containing 14, NLR family, pyrin domain containing 14, NOD5, PAN8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nlrp14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- PAAD/DAPIN/Pyrin domain
- NOD2 winged helix domain
- protein phosphatase 1 regulatory subunit 42
- Leucine rich repeat, ribonuclease inhibitor type
- Leucine rich repeat
- NACHT domain
- Death Domain Superfamily of protein-protein interaction domains
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Nlrp14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nlrp14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spermatogenesis
- cell differentiation
- regulation of inflammatory response
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding