Man2b1 Gene Summary [Rat]
Enables D-mannose binding activity and alpha-mannosidase activity. Predicted to be involved in oligosaccharide catabolic process and protein modification process. Predicted to act upstream of or within learning or memory and mannose metabolic process. Predicted to be located in extracellular space and nucleoplasm. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Man2b1 |
| Official Name | mannosidase, alpha, class 2B, member 1 [Source:RGD Symbol;Acc:3039] |
| Ensembl ID | ENSRNOG00000023910 |
| Bio databases IDs | |
| Aliases | mannosidase, alpha, class 2B, member 1 |
| Synonyms | Acidic Mannosidase, LAMAN, LYSMAN, lysosomal α-mannosidase, MANB, mannosidase 2, alpha B1, mannosidase 2, α B1, mannosidase alpha class 2B member 1, mannosidase, alpha, class 2B, member 1, mannosidase α class 2B member 1, mannosidase, α, class 2B, member 1, MGC72561 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Man2b1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Alpha mannosidase middle domain
- Glycosyl hydrolases family 38 N-terminal domain
- alpha-mannosidase
- GH38-57_N_LamB_YdjC_SF
- Alpha mannosidase, middle domain
- Glycosyl hydrolases family 38 C-terminal domain
- enzyme
- mannose binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alpha-mannosidosis
- hereditary disorder
- mental retardation
- Methylmalonic aciduria due to methylmalonyl-coa mutase deficiency
- global developmental delay
role in cell
- replication in
- abnormal morphology
- long-term potentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- azurophil granule lumen
- Extracellular Space
- lysosome
- lysosomal compartment
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Man2b1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- protein deglycosylation
- mannose metabolic process
- oligosaccharide catabolic process
- learning or memory
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- intracellular membrane-bounded organelle
- lysosomal lumen
- extracellular region
- azurophil granule lumen
- nucleoplasm
- lysosome
Molecular Function
What the gene product does at the molecular level
- alpha-mannosidase activity
- metal ion binding
- carbohydrate binding