Fgg Gene Summary [Rat]
Enables identical protein binding activity. Involved in cellular response to interleukin-1; cellular response to interleukin-6; and platelet maturation. Located in blood microparticle. Biomarker of myocardial infarction; obesity; pancreatitis; and pulmonary embolism. Human ortholog(s) of this gene implicated in brain small vessel disease; congenital afibrinogenemia; and multiple myeloma. Orthologous to human FGG (fibrinogen gamma chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgg |
| Official Name | fibrinogen gamma chain [Source:RGD Symbol;Acc:2613] |
| Ensembl ID | ENSRNOG00000025074 |
| Bio databases IDs | |
| Aliases | fibrinogen gamma chain |
| Synonyms | 3010002H13Rik, Fg gamma, Fg gamma chain, FGG isoform 1, Fg γ, Fg γ chain, fibrinogen gamma, fibrinogen gamma chain, Fibrinogen γ, Fibrinogen γ chain, PRO2061 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgg often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fibrinogen alpha/beta chain family
- integrin alpham beta2 binding domain
- cell adhesion molecule binding
- integrin alpha2b beta3 binding domain
- protein binding
- receptor binding
- structural molecule
- identical protein binding
- FReD
Pathways
Biological processes and signaling networks where the Fgg gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart disease
- venous thromboembolism
- hepatic fibrosis
- collagen-induced arthritis
- deep vein thrombosis
- chronic obstructive pulmonary disease
- hemophilia A
- congenital dysfibrinogenemia
- congenital afibrinogenemia
- Huntington disease
role in cell
- binding
- adhesion
- activation
- aggregation
- exocytosis by
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- blood microparticle
- cell surface
- cell cortex
- Nucleus
- Plasma Membrane
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- alpha granules
- synapse
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgg gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- macromolecular complex assembly
- positive regulation of vasoconstriction
- positive regulation of peptide hormone secretion
- positive regulation of substrate adhesion-dependent cell spreading
- fibrinolysis
- protein secretion
- positive regulation of exocytosis
- protein polymerization
- blood coagulation, fibrin clot formation
- cellular response to interleukin-6
- response to calcium ion
- plasminogen activation
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of heterotypic cell-cell adhesion
- cellular response to interleukin-1
- positive regulation of protein secretion
- negative regulation of endothelial cell apoptotic process
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum lumen
- extracellular space
- platelet alpha granule
- extracellular vesicular exosome
- blood microparticle
- external side of plasma membrane
- extracellular region
- plasma membrane
- fibrinogen complex
- cell surface
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- cell adhesion molecule binding
- structural molecule activity
- receptor binding
- extracellular matrix structural constituent