F13a1 Gene Summary [Rat]
Predicted to enable protein-glutamine gamma-glutamyltransferase activity. Predicted to be involved in blood coagulation, fibrin clot formation and peptide cross-linking. Predicted to act upstream of or within blood coagulation. Predicted to be located in cytoplasm and extracellular region. Biomarker of gastric ulcer. Human ortholog(s) of this gene implicated in artery disease (multiple); factor XIII deficiency; priapism; and thrombophilia (multiple). Orthologous to human F13A1 (coagulation factor XIII A chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | F13a1 |
| Official Name | coagulation factor XIII A1 chain [Source:RGD Symbol;Acc:621495] |
| Ensembl ID | ENSRNOG00000015957 |
| Bio databases IDs | |
| Aliases | coagulation factor XIII A1 chain |
| Synonyms | 1200014I03Rik, coagulation factor XIII A1 chain, coagulation factor XIII, A1 subunit, coagulation factor XIII A chain, F13A, Factor xiiia, Fxiiia |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat F13a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Transglutaminase-like superfamily
- activation domain
- Transglutaminase/protease-like homologues
- beta barrel
- protein-glutamine gamma-glutamyltransferase
- peptidase
- enzyme
- protein binding
- Transglutaminase family, C-terminal ig like domain
- Transglutaminase family
Pathways
Biological processes and signaling networks where the F13a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bleeding
- obesity
- Alzheimer disease
- COVID-19
- type II factor XIII deficiency
- essential thrombocythemia
- atherosclerosis
- colorectal cancer
- stroke
- collagen-induced arthritis
role in cell
- expression in
- number
- quantity
- activity
- formation
- destabilization
- replication in
- delivery
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat F13a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood coagulation, fibrin clot formation
- blood coagulation
- peptide cross-linking
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- blood microparticle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein-glutamine gamma-glutamyltransferase activity
- protein binding
- metal ion binding