Mn1 Gene Summary [Rat]
Predicted to be involved in negative regulation of osteoblast proliferation; positive regulation of vitamin D receptor signaling pathway; and regulation of cell cycle G1/S phase transition. Predicted to act upstream of or within intramembranous ossification. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mn1 |
| Official Name | MN1 proto-oncogene, transcriptional regulator [Source:RGD Symbol;Acc:1565571] |
| Ensembl ID | ENSRNOG00000027489 |
| Bio databases IDs | |
| Aliases | MN1 proto-oncogene, transcriptional regulator |
| Synonyms | CEBALID, dJ353E16.2, meningioma 1, MGCR, MGCR1, MGCR1-PEN, MN1 proto-oncogene, transcriptional regulator, RGD1565571 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription activation domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- CEBALID syndrome
- liver cancer
- hypoplasia
- endometriosis
- hereditary disorder
- androgenic alopecia
- breast carcinoma
- dyspnea
- amyotrophic lateral sclerosis
role in cell
- expression in
- proliferation
- activation in
- growth
- morphology
- differentiation
- transformation
- regulation
- membranous ossification by
- mineralization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intramembranous ossification
- regulation of transcription, DNA-dependent
- positive regulation of vitamin D receptor signaling pathway
- negative regulation of osteoblast proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding