Mn1 Gene Summary [Mouse]
Acts upstream of or within intramembranous ossification. Predicted to be located in nucleus. Is expressed in several structures, including brain; limb long bone; palatal shelf; tarsus; and ventral grey horn. Human ortholog(s) of this gene implicated in familial meningioma; meningioma; and myeloid leukemia. Orthologous to human MN1 (MN1 proto-oncogene, transcriptional regulator). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Mn1 |
| Official Name | meningioma 1 [Source:MGI Symbol;Acc:MGI:1261813] |
| Ensembl ID | ENSMUSG00000070576 |
| Bio databases IDs | |
| Aliases | meningioma 1 |
| Synonyms | CEBALID, dJ353E16.2, meningioma 1, MGCR, MGCR1, MGCR1-PEN, MN1 proto-oncogene, transcriptional regulator, RGD1565571 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription activation domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- CEBALID syndrome
- liver cancer
- hypoplasia
- endometriosis
- hereditary disorder
- androgenic alopecia
- breast carcinoma
- dyspnea
- amyotrophic lateral sclerosis
phenotypes
- abnormal cranial suture morphology
- abnormal frontal bone morphology
- abnormal interparietal bone morphology
- abnormal parietal bone morphology
- abnormal pterygoid process morphology
- abnormal sphenoid bone morphology
- abnormal suckling behavior
- abnormal supraoccipital bone morphology
- absent alisphenoid bone
- absent temporal bone squamous part
- absent vomer bone
- alisphenoid bone hypoplasia
- basisphenoid bone hypoplasia
- cleft secondary palate
- cyanosis
- large cranial foramen ovale
- large foramen rotundum
- lethargy
- maxillary shelf hypoplasia
- neonatal lethality incomplete penetrance
- palatal shelves fail to meet at midline
- palate bone hypoplasia
- palatine bone horizontal plate hypoplasia
- perinatal lethality complete penetrance
- presphenoid bone hypoplasia
- pterygoid bone hypoplasia
- respiratory distress
- temporal bone hypoplasia
- thin frontal bone
- thin interparietal bone
- thin parietal bone
- vomer bone hypoplasia
role in cell
- expression in
- proliferation
- activation in
- growth
- morphology
- differentiation
- transformation
- regulation
- membranous ossification by
- mineralization by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intramembranous ossification
- regulation of transcription, DNA-dependent
- positive regulation of vitamin D receptor signaling pathway
- negative regulation of osteoblast proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding