Casp12

Enables cysteine-type peptidase activity; endopeptidase activity; and protease binding activity. Involved in several processes, including cellular response to hydrogen peroxide; positive regulation of striated muscle cell apoptotic process; and protein autoprocessing. Predicted to be located in endoplasmic reticulum. Predicted to be part of NLRP1 inflammasome complex. Predicted to be active in cytosol. Used to study sciatic neuropathy. Biomarker of several diseases, including diabetes mellitus (multiple); heart disease (multiple); neurodegenerative disease (multiple); post-traumatic stress disorder; and ureteral obstruction. Orthologous to human CASP12 (caspase 12 (gene/pseudogene)). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Casp12 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Casp12 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.