Zfp277 Gene Summary [Rat]
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within cellular response to hydrogen peroxide and regulation of cellular senescence. Orthologous to human ZNF277 (zinc finger protein 277). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp277 |
| Official Name | zinc finger protein 277 [Source:RGD Symbol;Acc:1583856] |
| Ensembl ID | ENSRNOG00000045854 |
| Bio databases IDs | |
| Aliases | zinc finger protein 277 |
| Synonyms | 2410017E24Rik, NIRF4, NRIF4, Zfp277, zinc finger protein 277, ZNF277P |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Zfp277 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- C2H2 type zinc-finger (2 copies)
- Zinc-finger double-stranded RNA-binding
- nucleic acid binding
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- familial adenomatous polyposis
- dental caries
role in cell
- expression in
- proliferation
- response by
- senescence in
- replicative senescence
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Zfp277 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to hydrogen peroxide
- regulation of cellular senescence
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding