Ahsa1 Gene Summary [Rat]
Predicted to enable several functions, including ATPase activator activity; Hsp90 protein binding activity; and unfolded protein binding activity. Predicted to be involved in maintenance of unfolded protein; positive regulation of ATP-dependent activity; and protein folding. Predicted to be active in cytosol. Orthologous to human AHSA1 (activator of HSP90 ATPase activity 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ahsa1 |
| Official Name | activator of Hsp90 ATPase activity 1 [Source:RGD Symbol;Acc:1589285] |
| Ensembl ID | ENSRNOG00000048981 |
| Bio databases IDs | |
| Aliases | activator of Hsp90 ATPase activity 1 |
| Synonyms | activator of HSP90 ATPase activity 1, AHA1, AHA1, activator of heat shock protein ATPase 1, C14orf3, hAha1, p38 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ahsa1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SRPBCC domain
- ATPase stimulator
- heat shock protein binding
- protein binding
- chaperone binding
- Activator of Hsp90 ATPase, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- neoplasia
- organismal death
- cognitive impairment
- respiratory distress syndrome of the newborn
- nonalcoholic steatohepatitis
role in cell
- expression in
- apoptosis
- binding in
- proliferation
- growth
- bortezomib resistance
- phagocytosis
- phagocytosis by
- carfilzomib sensitivity
- interference in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ahsa1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of ATPase activity
- protein folding
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- chaperone binding
- Hsp90 protein binding
- ATPase activator activity