Crlf2 Gene Summary [Rat]
Enables cytokine activity. Predicted to be involved in several processes, including positive regulation of interleukin-5 production; positive regulation of mast cell activation; and positive regulation of receptor signaling pathway via STAT. Predicted to act upstream of or within inflammatory response. Predicted to be located in external side of plasma membrane. Orthologous to human CRLF2 (cytokine receptor like factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Crlf2 |
| Official Name | cytokine receptor-like factor 2 [Source:RGD Symbol;Acc:621078] |
| Ensembl ID | ENSRNOG00000049828 |
| Bio databases IDs | |
| Aliases | cytokine receptor-like factor 2 |
| Synonyms | CRL2, CRLF2Y, CRLM2, cytokine receptor-like factor 2, Ly114, Tpte2, TSLPR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Crlf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- binding protein
- cytoplasmic domain
- FN3
- transmembrane domain
- intracellular domain
- protein binding
- Fibronectin type 3 domain
- cytokine receptor
- transmembrane receptor
- coreceptor
Pathways
Biological processes and signaling networks where the Crlf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute lymphoblastic leukemia
- asthma
- tauopathy
- Philadelphia-like B-cell acute lymphoblastic leukemia
- hypoplasia
- idiopathic pulmonary fibrosis
- Philadelphia-like acute lymphoblastic leukemia
- amyloidosis
- T acute lymphoblastic leukemia
- colitis
role in cell
- expression in
- production in
- growth
- phosphorylation in
- activation
- proliferation
- quantity
- number
- differentiation
- frequency
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- nerve ending
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Crlf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytokine-mediated signaling pathway
- positive regulation of cell proliferation
- positive regulation of mast cell activation
- positive regulation of interleukin-5 production
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- receptor complex
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- cytokine binding
- cytokine receptor activity