Atp6v1c2 Gene Summary [Rat]
Predicted to enable identical protein binding activity and proton-transporting ATPase activity, rotational mechanism. Predicted to be involved in positive regulation of Wnt signaling pathway. Predicted to be part of vacuolar proton-transporting V-type ATPase, V1 domain. Orthologous to human ATP6V1C2 (ATPase H+ transporting V1 subunit C2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1c2 |
| Official Name | ATPase H+ transporting V1 subunit C2 [Source:RGD Symbol;Acc:1359430] |
| Ensembl ID | ENSRNOG00000050553 |
| Bio databases IDs | |
| Aliases | ATPase H+ transporting V1 subunit C2 |
| Synonyms | 1110038G14Rik, ATP6C2, ATPase, H+ transporting, lysosomal V1 subunit C2, ATPase H+ transporting V1 subunit C2, VMA5 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atp6v1c2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- H+-transporting two-sector ATPase
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- identical protein binding
- transporter
- Subunit C of vacuolar H+-ATPase (V-ATPase)
Pathways
Biological processes and signaling networks where the Atp6v1c2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- dementia
- COVID-19
- organismal death
- distal renal tubular acidosis
- colon epithelial cancer
- colon adenocarcinoma
role in cell
- proliferation
- expression in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atp6v1c2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
- positive regulation of Wnt receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- vacuolar proton-transporting V-type ATPase, V1 domain
- extracellular vesicular exosome
- cytosol
- lysosomal membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- proton-transporting ATPase activity, rotational mechanism