Col25a1 Gene Summary [Rat]
Predicted to enable amyloid-beta binding activity; heparin binding activity; and identical protein binding activity. Predicted to act upstream of or within axonogenesis involved in innervation. Predicted to be located in extracellular space and plasma membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 5. Orthologous to human COL25A1 (collagen type XXV alpha 1 chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Col25a1 |
| Official Name | collagen type XXV alpha 1 chain [Source:RGD Symbol;Acc:1590105] |
| Ensembl ID | ENSRNOG00000050706 |
| Bio databases IDs | |
| Aliases | collagen type XXV alpha 1 chain |
| Synonyms | 2700062B08Rik, AMY, CFEOM5, CLAC, CLAC-P, collagen, type XXV, alpha 1, collagen type XXV alpha 1 chain, collagen, type XXV, α 1, collagen type XXV α 1 chain, LOC102553088 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Col25a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- NC1 domain
- nc3 domain
- Collagen triple helix repeat (20 copies)
- coiled-coil domain
- beta-amyloid binding
- heparin binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Col25a1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- Alzheimer disease
- Dupuytren contracture
- Peyronie disease
- congenital fibrosis of extraocular muscles type 5
- respiratory failure
- centronuclear myopathy
- diabetic foot ulcer disorder
- burn
- cyanosis
role in cell
- apoptosis
- number
- loss
- abnormal morphology
- innervation by
- degeneration
- proteolysis
- activation
- branching
- aggregation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Extracellular Space
- Plasma Membrane
- endoplasmic reticulum lumen
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Col25a1 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- collagen
- membrane
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- extracellular matrix structural constituent conferring tensile strength
- heparin binding
- beta-amyloid binding