LOC100911295 Gene Summary [Rat]
The protein encoded by this gene binds nucleosomal DNA and is associated with transcriptionally active chromatin. Along with a similar protein, HMG17, the encoded protein may help maintain an open chromatin configuration around transcribable genes. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | LOC100911295 |
| Official Name | non-histone chromosomal protein HMG-14-like [Source:RGD Symbol;Acc:6494054] |
| Ensembl ID | ENSRNOG00000050978 |
| Bio databases IDs | |
| Aliases | non-histone chromosomal protein HMG-14-like |
| Synonyms | high mobility group nucleosomal binding domain 1, high mobility group nucleosome binding domain 1, HMG-14, LOC100911295 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100911295 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- HMG14 and HMG17
- domain in high mobilty group proteins HMG14 and HMG 17
- chromatin binding
- protein binding
- DNA binding
Pathways
Biological processes and signaling networks where the Loc100911295 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- benign neoplasia
- cancer
- neoplasia
- metastasis
- advanced cancer
- angiomatosis
- glioma
- glioma formation
- pheochromocytoma formation
- abdominal paraganglioma formation
role in cell
- proliferation
- growth
- G2/M phase
- differentiation
- remodeling
- sensitivity
- survival
- function
- organization
- transcription-coupled nucleotide-excision repair in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100911295 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of development, heterochronic
- post-embryonic camera-type eye morphogenesis
- transcription-coupled nucleotide-excision repair
- response to UV-C
- pyrimidine dimer repair by nucleotide-excision repair
- chromatin organization
- regulation of epithelial cell proliferation
- positive regulation of transcription elongation, DNA-dependent
- response to UV-B
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- female germ cell nucleus
- nucleus
- cytoplasm
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- nucleosomal DNA binding
- chromatin binding