Ppp1r8 Gene Summary [Rat]
Predicted to enable molecular function inhibitor activity and protein phosphatase regulator activity. Predicted to act upstream of or within cell population proliferation. Predicted to be located in nuclear speck. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ppp1r8 |
| Official Name | protein phosphatase 1, regulatory subunit 8 [Source:RGD Symbol;Acc:1306280] |
| Ensembl ID | ENSRNOG00000059550 |
| Bio databases IDs | |
| Aliases | protein phosphatase 1, regulatory subunit 8 |
| Synonyms | 6330548N22RIK, ARD-1, NIPP-1, PRO2047, protein phosphatase 1 regulatory subunit 8, protein phosphatase 1, regulatory subunit 8 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ppp1r8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ribonuclease E
- FHA domain
- type 1 serine/threonine specific protein phosphatase inhibitor
- phosphatase
- protein phosphatase regulator
- central domain
- Forkhead associated domain
- endoribonuclease
- protein binding
- forkhead associated (FHA) domain superfamily
- RNA binding
Pathways
Biological processes and signaling networks where the Ppp1r8 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
role in cell
- proliferation
- survival
- cohesion
- assembly
- cohesion in
- josamycin sensitivity
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ppp1r8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- RNA splicing
- mRNA processing
- negative regulation of protein dephosphorylation
- RNA catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- spliceosomal complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein serine/threonine phosphatase inhibitor activity
- DNA binding
- protein binding
- RNA binding
- endonuclease activity
- ribonuclease E activity
- mRNA binding