Ppp1r8 Gene Summary [Mouse]

Enables protein phosphatase regulator activity. Acts upstream of or within cell population proliferation. Predicted to be located in nucleoplasm. Predicted to be part of spliceosomal complex. Predicted to be active in nuclear speck. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; adrenal gland; and brain. Orthologous to human PPP1R8 (protein phosphatase 1 regulatory subunit 8). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Ppp1r8
Official Name
protein phosphatase 1, regulatory subunit 8 [Source:MGI Symbol;Acc:MGI:2140494]
Ensembl ID
ENSMUSG00000028882
Bio databases IDs NCBI: 100336 Ensembl: ENSMUSG00000028882
Aliases protein phosphatase 1, regulatory subunit 8
Synonyms 6330548N22RIK, ARD-1, NIPP-1, PRO2047, protein phosphatase 1 regulatory subunit 8, protein phosphatase 1, regulatory subunit 8
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ppp1r8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • ribonuclease E
  • FHA domain
  • type 1 serine/threonine specific protein phosphatase inhibitor
  • phosphatase
  • protein phosphatase regulator
  • central domain
  • Forkhead associated domain
  • endoribonuclease
  • protein binding
  • forkhead associated (FHA) domain superfamily
  • RNA binding

Pathways

Biological processes and signaling networks where the Ppp1r8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • systemic lupus erythematosus
regulated by
regulates
role in cell
  • proliferation
  • survival
  • cohesion
  • assembly
  • cohesion in
  • josamycin sensitivity
  • morphology

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • Cytoplasm
  • nucleoplasm
  • nuclear speckles

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ppp1r8 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cell proliferation
  • RNA splicing
  • mRNA processing
  • negative regulation of protein dephosphorylation
  • RNA catabolic process

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasm
  • nuclear speck
  • spliceosomal complex
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • protein serine/threonine phosphatase inhibitor activity
  • DNA binding
  • protein binding
  • RNA binding
  • endonuclease activity
  • ribonuclease E activity
  • mRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.