Adra1b Gene Summary [Rat]
Enables alpha1-adrenergic receptor activity. Involved in several processes, including positive regulation of cytosolic calcium ion concentration; response to estrogen; and response to steroid hormone. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and intercalated disc. Biomarker of polycystic ovary syndrome. Orthologous to human ADRA1B (adrenoceptor alpha 1B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adra1b |
| Official Name | adrenoceptor alpha 1B [Source:RGD Symbol;Acc:2054] |
| Ensembl ID | ENSRNOG00000060087 |
| Bio databases IDs | |
| Aliases | adrenoceptor alpha 1B |
| Synonyms | [a]1b, ADRA1, adrenergic receptor, alpha 1b, adrenergic receptor, α 1b, adrenoceptor alpha 1B, adrenoceptor α 1B, Alpha-1 AR, Alpha 1b adrenoceptor, alpha1B AR, LOC105377689, α-1 AR, α 1b adrenergic receptor, α 1b adrenoceptor, α-1b AR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adra1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- NPXXY motif
- extracellular domain
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- DRY motif
- helical domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- acidic domain
- arginine rich motif
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- alpha1-adrenergic receptor
- protein heterodimerization
Pathways
Biological processes and signaling networks where the Adra1b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- prostate cancer
- infection
- nausea
- agitation
- traumatic brain injury
- postoperative nausea and vomiting
- delirium
- hypertension
- postoperative pain
role in cell
- phosphorylation in
- apoptosis
- number
- proliferation
- replication in
- size
- cell cycle progression
- transformation
- reorganization
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- membrane surface
- cellular membrane
- Nucleus
- intercellular junctions
- nuclear envelope
- intercalated disks
- transverse tubules
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adra1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- adenylate cyclase-activating adrenergic receptor signaling pathway
- cell-cell signaling
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- phospholipase C-activating G-protein coupled receptor signaling pathway
- regulation of cardiac muscle contraction
- intracellular signal transduction
- regulation of vasoconstriction
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- caveola
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein heterodimerization activity
- alpha1-adrenergic receptor activity