Mgst2 Gene Summary [Rat]
Enables glutathione peroxidase activity; glutathione transferase activity; and leukotriene-C4 synthase activity. Involved in response to lipopolysaccharide. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Predicted to be active in endoplasmic reticulum and nuclear envelope. Orthologous to human MGST2 (microsomal glutathione S-transferase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mgst2 |
| Official Name | microsomal glutathione S-transferase 2 [Source:RGD Symbol;Acc:1311218] |
| Ensembl ID | ENSRNOG00000061857 |
| Bio databases IDs | |
| Aliases | microsomal glutathione S-transferase 2 |
| Synonyms | GST2, MGST-II, microsomal glutathione S-transferase 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mgst2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- glutathione transferase
- MAPEG family
- enzyme
- protein binding
- glutathione peroxidase
- leukotriene-C4 synthase
- identical protein binding
Pathways
Biological processes and signaling networks where the Mgst2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- progressive familial intrahepatic cholestasis type 1
- vesicoureteral reflux
regulates
- cysteinyl-leukotriene
- lipid
- phospholipid
- glutathione
- leukotriene
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- intracellular membrane-bounded organelle
- cellular membrane
- Plasma Membrane
- vesicles
- endoplasmic reticulum membrane
- caveolae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mgst2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- leukotriene biosynthetic process
- positive regulation of inflammatory response
- lipid metabolic process
- glutathione biosynthetic process
- response to lipopolysaccharide
- membrane lipid catabolic process
- response to organic nitrogen
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- nuclear envelope
- intracellular membrane-bounded organelle
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- glutathione peroxidase activity
- protein binding
- glutathione binding
- enzyme activator activity
- glutathione transferase activity
- leukotriene-C4 synthase activity