IFNA13 Gene Summary [Human]
This gene is a member of the alpha interferon gene cluster on chromosome 9. The encoded cytokine is a member of the type I interferon family that is produced in response to viral infection as a key part of the innate immune response with potent antiviral, antiproliferative and immunomodulatory properties. This cytokine, like other type I interferons, binds a plasma membrane receptor made of IFNAR1 and IFNAR2 that is ubiquitously expressed, and thus is able to act on virtually all body cells. This cytokine is upregulated in preeclamptic placentas and is thought to be a mediator of preeclampsia. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | IFNA13 |
| Official Name | interferon alpha 13 [Source:HGNC Symbol;Acc:HGNC:5419] |
| Ensembl ID | ENSG00000233816 |
| Bio databases IDs | |
| Aliases | interferon alpha 13 |
| Synonyms | IFL, IFN, IFNA@, IFNA1, IFNA13, IFNAD, IFN-ALPHA, IFN-alpha1, IFN-alphaD, IFN-delta, IFN-α, IFN-δ, INF-alpha, INF-α, interferon alpha 1, interferon alpha 13, interferon α 1, Interferon α 13, leIF D |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNA13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IFab
- interferon-alpha/beta receptor binding
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the IFNA13 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic inflammatory myopathy
- epithelial cancer
- epithelial neoplasia
- cancer
- tumorigenesis
- psoriasis
- renal cell cancer
- kidney adenocarcinoma formation
- renal cancer
- abdominal cancer
role in cell
- expression in
- activation in
- proliferation
- production in
- activation
- phosphorylation in
- binding
- differentiation
- colony formation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNA13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- natural killer cell activation involved in immune response
- B cell differentiation
- cytokine-mediated signaling pathway
- response to exogenous dsRNA
- humoral immune response
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- defense response to virus
- B cell proliferation
- adaptive immune response
- T cell activation involved in immune response
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- interferon-alpha/beta receptor binding
- cytokine activity