IFNA5 Gene Summary [Human]
Predicted to enable cytokine activity and type I interferon receptor binding activity. Predicted to be involved in several processes, including B cell activation; lymphocyte activation involved in immune response; and positive regulation of peptidyl-serine phosphorylation of STAT protein. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IFNA5 |
| Official Name | interferon alpha 5 [Source:HGNC Symbol;Acc:HGNC:5426] |
| Ensembl ID | ENSG00000147873 |
| Bio databases IDs | |
| Aliases | interferon alpha 5 |
| Synonyms | IFN-alpha-5, IFN-alphaG, IFN-α-5, INA5, INFA5, interferon alpha 5, interferon α 5, leIF G |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFNA5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hematopoietin/interferon-class (D200-domain) cytokine receptor ligand
- IFab
- cytokine
Pathways
Biological processes and signaling networks where the IFNA5 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- IL-15 Production
- Interferon Signaling
- Neuroinflammation Signaling Pathway
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- psoriasis
role in cell
- production in
- proliferation
- expression in
- activation in
- phosphorylation in
- upregulation in
- differentiation
- activation
- maturation
- antiviral response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFNA5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- natural killer cell activation involved in immune response
- B cell differentiation
- cytokine-mediated signaling pathway
- response to exogenous dsRNA
- humoral immune response
- positive regulation of peptidyl-serine phosphorylation of STAT protein
- adaptive immune response
- defense response to virus
- B cell proliferation
- T cell activation involved in immune response
- type I interferon-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- interferon-alpha/beta receptor binding
- cytokine activity
- cytokine receptor binding