Fastk Gene Summary [Mouse]
Predicted to enable RNA binding activity and protein serine/threonine kinase activity. Predicted to be involved in mitochondrial RNA processing; protein phosphorylation; and regulation of gene expression. Located in nuclear speck. Is expressed in brain; gut; male reproductive gland or organ; metanephros; and thoracic segment skeleton. Orthologous to human FASTK (Fas activated serine/threonine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fastk |
| Official Name | Fas-activated serine/threonine kinase [Source:MGI Symbol;Acc:MGI:1913837] |
| Ensembl ID | ENSMUSG00000028959 |
| Bio databases IDs | |
| Aliases | Fas-activated serine/threonine kinase |
| Synonyms | 0610011K02Rik, 610011K02Rik, Fas-activated serine/threonine kinase, FAST, Fast Kinase, FLJ13079 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fastk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- TIA-1 binding domain
- FAST kinase-like protein, subdomain 1
- RNA-editing substrate-binding complex subunit 6 (RESC6) and related proteins
- FAST kinase-like protein, subdomain 2
- protein binding
- PDDEXK family nucleases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fastk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of mitochondrial mRNA stability
- regulation of RNA splicing
- apoptotic signaling pathway
- mitochondrial RNA processing
- protein phosphorylation
Cellular Component
Where in the cell the gene product is active
- ribonucleoprotein granule
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- protein binding
- Fas-activated serine/threonine kinase activity
- protein serine/threonine kinase activity