ATF1 Gene Summary

This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

Details

Type
Protein Coding
Official Symbol
ATF1
Official Name
activating transcription factor 1 [Source:HGNC Symbol;Acc:HGNC:783]
Ensembl ID
ENSG00000123268
Bio databases IDs NCBI: 466 Ensembl: ENSG00000123268
Aliases activating transcription factor 1
Synonyms
activating transcription factor 1,TREB36
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
  • transcription regulator
  • DNA binding domain
  • nucleic acid binding
  • Basic region leucine zipper
  • leucine zipper domain
  • protein binding
  • sequence-specific DNA binding
  • identical protein binding
  • DNA binding
  • bZIP domain
  • RNA polymerase II transcription factor activity, sequence-specific DNA binding
  • binding protein
  • double-stranded DNA binding
  • pKID domain
  • bZIP
  • transcription factor activity
  • basic region leucin zipper

Pathways

Biological processes and signaling networks where the ATF1 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • colorectal cancer
  • sudden cardiac arrest
  • colorectal adenoma
  • colorectal adenoma formation
  • colonic polyp
  • side effect
regulated by
  • tetradecanoylphorbol acetate
  • ionomycin
  • Ca2+
  • CaMKII
  • 1-O-hexadecyl-2-N-methylcarbamol-sn-glycerol-3-phosphocholine
  • lipopolysaccharide
  • TNF
  • CDK3
  • NRG1
  • LEP
regulates
role in cell
  • apoptosis
  • colony formation
  • production in
  • growth
  • expression in
  • cell viability
  • invasion
  • development
  • survival
  • cell focus formation

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • nucleoplasm
  • pronucleus
  • chromatin

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the ATF1 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • macromolecular complex assembly
  • response to purine-containing compound
  • response to cobalt ion
  • positive regulation of DNA replication
  • positive regulation of neuron projection development
  • positive regulation of transcription from RNA polymerase II promoter
  • cAMP-mediated signaling
  • regulation of transcription from RNA polymerase II promoter

cellular COMPONENT

Where in the cell the gene product is active
  • nucleus
  • chromatin
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • identical protein binding
  • sequence-specific DNA binding transcription factor activity
  • protein binding
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding
  • RNA polymerase II regulatory region sequence-specific DNA binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  • sequence-specific DNA binding RNA polymerase II transcription factor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.