Cd48 Gene Summary [Mouse]
Acts upstream of or within T cell activation and signal transduction. Located in external side of plasma membrane. Is expressed in several structures, including adipose tissue; bone; hemolymphoid system; liver; and lung. Orthologous to human CD48 (CD48 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd48 |
| Official Name | CD48 antigen [Source:MGI Symbol;Acc:MGI:88339] |
| Ensembl ID | ENSMUSG00000015355 |
| Bio databases IDs | |
| Aliases | CD48 antigen |
| Synonyms | BCM1, BCM1 surface antigen, BLAST, BLAST-1, CD48 ANTIGEN, CD48 molecule, hCD48, mCD48, MEM-102, Sgp-60, SLAMF2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cd48 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- membrane distal domain
- extracellular domain
- cytoplasmic domain
- immunoglobulin domain
- Immunoglobulin like
- receptor agonist activity
- protein binding
- membrane-proximal domain
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Cd48 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- endometriosis
- non-small cell lung cancer
- squamous-cell carcinoma
- squamous cell cancer
- acute myeloid leukemia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- plasma cell myeloma
role in cell
- proliferation
- apoptosis
- cellular infiltration by
- adhesion
- activation in
- activation
- recruitment
- fratricide
- binding
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- Extracellular Space
- cellular membrane
- plasma membrane extracellular face
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cd48 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- membrane
- membrane raft
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding