Grn Gene Summary [Mouse]
Predicted to enable protein-folding chaperone binding activity. Involved in several processes, including glial cell activation; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and positive regulation of cell population proliferation. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is active in cerebellar climbing fiber to Purkinje cell synapse. Is expressed in several structures, including brain; early conceptus; gonad; placenta; and skin. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grn |
| Official Name | granulin [Source:MGI Symbol;Acc:MGI:95832] |
| Ensembl ID | ENSMUSG00000034708 |
| Bio databases IDs | |
| Aliases | granulin |
| Synonyms | acrogranin, CLN11, epithelin, FTD2, GEP, GP88, Granulin, granulin precursor, PCDGF, PEPI, PGRN, Proepithelin, Progranulin |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Granulin
- granulin repeat f
- Granulin repeat p
- Granulin repeat a
- granulin repeat c
- Granulin repeat g
- Granulin repeat d
- protein binding
- chaperone binding
- growth factor
- granulin repeat b
- Granulin repeat e
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
- parkinsonism
- metabolic syndrome X
- weight loss
- epithelial cancer
- liver cancer
- androgenic alopecia
- ubiquitin-positive frontotemporal dementia
- neuronal ceroid lipofuscinosis 11
- astrocytosis
phenotypes
- abnormal body weight
- abnormal brain morphology
- abnormal chemokine secretion
- abnormal circulating hormone level
- abnormal cone electrophysiology
- abnormal dendrite morphology
- abnormal dendritic spine morphology
- abnormal ejaculation
- abnormal excitatory postsynaptic potential
- abnormal hepatocyte morphology
- abnormal hepatocyte physiology
- abnormal hypothalamus morphology
- abnormal hypothalamus secretion
- abnormal kidney physiology
- abnormal liver morphology
- abnormal liver parenchyma morphology
- abnormal long term spatial reference memory
- abnormal macrophage physiology
- abnormal microglial cell physiology
- abnormal nervous system physiology
- abnormal neurite morphology
- abnormal neuron physiology
- abnormal paraventricular hypothalamic nucleus morphology
- abnormal renal water homeostasis
- abnormal response to novel object
- abnormal retinal ganglion cell morphology
- abnormal retinal nerve fiber layer morphology
- abnormal social investigation
- abnormal spatial learning
- abnormal supraoptic nucleus morphology
- abnormal synapse morphology
- abnormal thalamus neuron morphology
- abnormal zinc homeostasis
- astrocytosis
- decreased a wave amplitude
- decreased aggression towards males
- decreased b wave amplitude
- decreased body weight
- decreased brain weight
- decreased dendritic spine density
- decreased grooming behavior
- decreased survivor rate
- decreased urine creatinine level
- decreased urine magnesium level
- decreased urine osmolality
- decreased urine potassium level
- dilated kidney collecting duct
- dilated renal tubules
- enlarged kidney
- impaired contextual conditioning behavior
- impaired coordination
- impaired synaptic plasticity
- increased aggression towards males
- increased anxiety-related response
- increased circulating antidiuretic hormone level
- increased circulating ghrelin level
- increased fluid intake
- increased food intake
- increased grooming behavior
- increased hepatocyte karyomegaly
- increased interleukin-1 beta secretion
- increased interleukin-10 secretion
- increased interleukin-12 secretion
- increased interleukin-6 secretion
- increased kidney weight
- increased liver weight
- increased susceptibility to bacterial infection
- increased susceptibility to dopaminergic neuron neurotoxicity
- increased susceptibility to injury
- increased thigmotaxis
- increased tumor necrosis factor secretion
- kidney inflammation
- lipofuscinosis
- loss of dopaminergic neurons
- microgliosis
- nervous system inclusion bodies
- neurodegeneration
- neuronal cytoplasmic inclusions
- polydipsia
- polyuria
- premature death
- reduced long term potentiation
- retinal ganglion cell degeneration
- skin lesions
- tau protein deposits
role in cell
- formation
- apoptosis
- growth
- expression in
- production in
- accumulation in
- differentiation
- autophagy in
- cell death
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- glutaminergic synapse
- azurophil granule lumen
- Cytoplasm
- cell-associated matrix
- intracellular space
- cellular membrane
- Plasma Membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- trans Golgi network
- lysosome membrane
- synapse
- late endosomes
- excitatory synapses
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lysosome organization
- negative regulation of respiratory burst involved in inflammatory response
- signal transduction
- lysosomal transport
- lysosomal lumen acidification
- microglial cell activation involved in immune response
- astrocyte activation involved in immune response
- positive regulation of neuron apoptotic process
- positive regulation of angiogenesis
- positive regulation of defense response to bacterium
- negative regulation of neuron apoptotic process
- positive regulation of axon regeneration
- regulation of inflammatory response
- protein stabilization
- positive regulation of endothelial cell migration
- positive regulation of epithelial cell proliferation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- late endosome
- endoplasmic reticulum
- Golgi apparatus
- extracellular region
- lysosomal membrane
- plasma membrane
- lysosome
- extracellular space
- trans-Golgi network
- endosome
- extracellular vesicular exosome
- membrane
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- RNA binding
- chaperone binding
- cytokine activity