MAST4 Gene Summary [Human]

This gene encodes a member of the microtubule-associated serine/threonine protein kinases. The proteins in this family contain a domain that gives the kinase the ability to determine its own scaffold to control the effects of their kinase activities. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]

Details

Type
Protein Coding
Official Symbol
MAST4
Official Name
microtubule associated serine/threonine kinase family member 4 [Source:HGNC Symbol;Acc:HGNC:19037]
Ensembl ID
ENSG00000069020
Bio databases IDs NCBI: 375449 Ensembl: ENSG00000069020
Aliases microtubule associated serine/threonine kinase family member 4
Synonyms 4930420O11Rik, microtubule associated serine/threonine kinase family member 4, mKIAA0303, RGD1310139
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAST4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • Domain present in PSD-95, Dlg, and ZO-1/2
  • protein serine/threonine kinase
  • Protein kinase (unclassified specificity)
  • Protein Kinases, catalytic domain
  • Protein tyrosine and serine/threonine kinase
  • canonical PDZ domain
  • Protein kinase domain
  • PDZ domain
  • Domain of unknown function (DUF1908)
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • COVID-19
  • epithelial cancer
  • prostate cancer
  • breast cancer
  • coronary artery disease
  • metabolic syndrome X
  • colorectal cancer
  • chronic lymphocytic leukemia
  • bullous pemphigoid
  • non-insulin-dependent diabetes mellitus
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Unknown

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human MAST4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • cytoskeleton organization
  • peptidyl-serine phosphorylation
  • intracellular signal transduction

Cellular Component

Where in the cell the gene product is active
  • cytoplasm

Molecular Function

What the gene product does at the molecular level
  • magnesium ion binding
  • ATP binding
  • protein serine/threonine kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.