Fgf9 Gene Summary [Mouse]
Predicted to enable fibroblast growth factor receptor binding activity and growth factor activity. Involved in eye development. Acts upstream of or within several processes, including positive regulation of cell population proliferation; regulation of signal transduction; and skeletal system development. Predicted to be located in basement membrane. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Used to study lung cancer; multiple synostoses syndrome; and pleuropulmonary blastoma. Human ortholog(s) of this gene implicated in kidney cancer and multiple synostoses syndrome 3. Orthologous to human FGF9 (fibroblast growth factor 9). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf9 |
| Official Name | fibroblast growth factor 9 [Source:MGI Symbol;Acc:MGI:104723] |
| Ensembl ID | ENSMUSG00000021974 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 9 |
| Synonyms | Eks, Fgf4b, fibroblast growth factor 9, GAF, glia-activating factor, HBFG-9, HBGF-9, SYNS3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- FGF core homology domain
- fibroblast growth factor receptor binding
- growth factor
Pathways
Biological processes and signaling networks where the Fgf9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- cancer
- epithelial cancer
- epithelial neoplasia
- metastasis
- hepatocellular carcinoma
- hypoxia
- Sjögren syndrome
- prostate cancer
phenotypes
- abnormal body wall morphology
- abnormal embryo size
- abnormal motor learning
- abnormal retinal vasculature morphology
- cataract
- enlarged heart
- hyperactivity
- increased grip strength
- increased mean corpuscular hemoglobin
- increased startle reflex
- preweaning lethality complete penetrance
- respiratory system phenotype
- shortened RR interval
- abnormal Leydig cell differentiation
- abnormal RR interval
- abnormal Sertoli cell development
- abnormal branching involved in lung morphogenesis
- abnormal cartilage development
- abnormal cecum morphology
- abnormal coccyx morphology
- abnormal cochlea morphology
- abnormal digestive system physiology
- abnormal fetal cardiomyocyte proliferation
- abnormal grip strength
- abnormal heart development
- abnormal heart rate
- abnormal humerus morphology
- abnormal incisor morphology
- abnormal intervertebral disk morphology
- abnormal joint morphology
- abnormal knee joint morphology
- abnormal lens development
- abnormal limb development
- abnormal long bone morphology
- abnormal lung morphology
- abnormal lung-associated mesenchyme development
- abnormal mesenchymal cell proliferation involved in lung development
- abnormal primary sex determination
- abnormal radius morphology
- abnormal small intestine crypts of Lieberkuhn morphology
- abnormal small intestine morphology
- abnormal sternum morphology
- abnormal suckling behavior
- abnormal temporal bone morphology
- abnormal testis cord formation
- abnormal testis morphology
- abnormal tooth development
- abnormal tympanic ring morphology
- abnormal vertebral arch morphology
- abnormal vision
- abnormal voluntary movement
- calcified joint
- caudal vertebral fusion
- cleft palate
- cleft secondary palate
- curly tail
- cyanosis
- decreased fetal weight
- decreased lung weight
- decreased number of peritubular myoid cells
- delayed bone ossification
- dilated heart atrium
- dilated heart left ventricle
- dilated heart right ventricle
- dilated heart ventricle
- disorganized testis cords
- enlarged Meckel's cartilage
- enlarged eye anterior chamber
- enlarged heart atrium
- epididymis hypoplasia
- exophthalmos
- fused joints
- fusion of vertebral arches
- heart hypoplasia
- high forehead
- hypopnea
- hypoxia
- increased bone ossification
- increased chondrocyte number
- increased diameter of femur
- increased diameter of fibula
- increased diameter of humerus
- increased diameter of radius
- increased diameter of tibia
- increased diameter of ulna
- kinked tail
- lethality at weaning incomplete penetrance
- midface hypoplasia
- misaligned incisors
- neonatal lethality complete penetrance
- no abnormal phenotype detected
- ocular hypertelorism
- ovotestis
- pallor
- perinatal lethality complete penetrance
- postnatal growth retardation
- postnatal lethality
- postnatal lethality incomplete penetrance
- premature coronal suture closure
- premature sagittal suture closure
- primary sex reversal
- pulmonary hypoplasia
- respiratory distress
- respiratory failure
- short femur
- short fibula
- short humerus
- short limbs
- short nasal bone
- short premaxilla
- short radius
- short sternum
- short tail
- short tibia
- short ulna
- small lens
- small lung
- synostosis
- testis hypoplasia
- vertebral fusion
- wide ribs
role in cell
- expression in
- phosphorylation in
- proliferation
- development
- apoptosis
- number
- cell death
- survival
- accumulation
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- Golgi Apparatus
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- lung-associated mesenchyme development
- positive regulation of cardiac muscle cell proliferation
- male gonad development
- positive regulation of cell proliferation
- chondrocyte differentiation
- fibroblast growth factor receptor signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- activin receptor signaling pathway
- embryonic limb morphogenesis
- embryonic digestive tract development
- positive regulation of cell division
- angiogenesis
- positive regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of activin receptor signaling pathway
- stem cell proliferation
- osteoblast differentiation
- canonical Wnt receptor signaling pathway
- positive regulation of epithelial cell proliferation
- Sertoli cell proliferation
- signal transduction
- cell-cell signaling
- positive regulation of canonical Wnt receptor signaling pathway
- smoothened signaling pathway
- positive regulation of mesenchymal cell proliferation
- positive regulation of MAPK cascade
- embryonic skeletal system development
- cardiac muscle cell proliferation
- substantia nigra development
- organ morphogenesis
- regulation of timing of cell differentiation
- male sex determination
- vascular endothelial growth factor receptor signaling pathway
- eye development
- protein import into nucleus
- positive regulation of gene expression
- positive regulation of stem cell proliferation
- inner ear morphogenesis
- positive regulation of smoothened signaling pathway
- positive regulation of protein phosphorylation
- cell differentiation
- positive regulation of reproductive process
- negative regulation of Wnt receptor signaling pathway
- regulation of cell migration
- mesenchymal cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- heparin binding
- fibroblast growth factor receptor binding