PDCD1 Gene Summary [Human]
Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | PDCD1 |
| Official Name | programmed cell death 1 [Source:HGNC Symbol;Acc:HGNC:8760] |
| Ensembl ID | ENSG00000188389 |
| Bio databases IDs | |
| Aliases | programmed cell death 1 |
| Synonyms | AIMTBS, B7H1, CD279, hPD-1, hPD-l, hSLE1, LOC100911478, Ly101, PD, PD-1, Pd-1 receptor, Pdc1, PhLP, programmed cell death 1, SLEB2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- immunoreceptor tyrosine-based inhibition motif
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- cytosolic tail domain
- transmembrane receptor
- Immunoglobulin V-set domain
- immunoreceptor tyrosine switch motif
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- plasma cell myeloma
- acute myeloid leukemia
- neoplasia
- epithelial neoplasia
- solid tumor
- breast cancer
- Hodgkin disease
- epithelial cancer
- cancer
- Hodgkin lymphoma
role in cell
- phosphorylation in
- expression in
- apoptosis
- cell death
- growth
- activation in
- activation
- proliferation
- cell viability
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell mediated immune response to tumor cell
- negative regulation of tolerance induction
- apoptotic process
- humoral immune response
- negative regulation of B cell apoptotic process
- adaptive immune response
- positive regulation of T cell apoptotic process
- negative regulation of T cell activation
- negative regulation of immune response
- B cell apoptotic process
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity