PELI1 Gene Summary [Human]
Enables ubiquitin protein ligase activity. Involved in several processes, including negative regulation of necroptotic process; protein polyubiquitination; and response to lipopolysaccharide. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | PELI1 |
| Official Name | pellino E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:8827] |
| Ensembl ID | ENSG00000197329 |
| Bio databases IDs | |
| Aliases | pellino E3 ubiquitin protein ligase 1 |
| Synonyms | 2810468L03Rik, A930031K15Rik, D11Ertd676e, PELLINO 1, pellino E3 ubiquitin protein ligase 1, PELLINO HOMOLOG 1, RGD1564594 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PELI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- ubiquitin-protein transferase activity
- enzyme
- protein binding
- Pellino
Pathways
Biological processes and signaling networks where the PELI1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- insomnia
- breast cancer
- celiac disease
- cardiac fibrosis
- heart disease
- experimental autoimmune encephalomyelitis
- Kawasaki disease
- productive infection by HIV-1
role in cell
- proliferation
- expression in
- number
- activation in
- apoptosis
- phosphorylation in
- binding in
- quantity
- cellular infiltration by
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PELI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 3 signaling pathway
- DNA repair
- protein K48-linked ubiquitination
- positive regulation of toll-like receptor 4 signaling pathway
- regulation of Toll signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to dsRNA
- regulation of necroptosis
- negative regulation of necroptosis
- proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of T cell proliferation
- T cell proliferation
- positive regulation of protein ubiquitination
- positive regulation of B cell proliferation
- protein K63-linked ubiquitination
- response to lipopolysaccharide
- positive regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin-ubiquitin ligase activity