Rnasel Gene Summary [Mouse]
Enables ribonucleoprotein complex binding activity. Acts upstream of or within fat cell differentiation; positive regulation of D-glucose import; and regulation of mRNA stability. Predicted to be located in nuclear matrix. Is expressed in several structures, including brain and retina nuclear layer. Human ortholog(s) of this gene implicated in Lynch syndrome and prostate cancer. Orthologous to human RNASEL (ribonuclease L). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnasel |
| Official Name | ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) [Source:MGI Symbol;Acc:MGI:1098272] |
| Ensembl ID | ENSMUSG00000066800 |
| Bio databases IDs | |
| Aliases | ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) |
| Synonyms | E230029I04Rik, HPC1, PRCA1, Ribonuclease L, ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent), RNASEL 80KD, RNS4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnasel often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ankyrin repeats (many copies)
- protein kinase
- rRNA binding
- Ankyrin repeats (3 copies)
- PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
- enzyme
- protein binding
- 5' phosphomonoester producing endoribonuclease
- identical protein binding
- pseudo kinase domain
- Ankyrin repeat
- RNA binding
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- Non-5' phosphomonoester producing endoribonuclease
- ribonuclease
- ribonucleoprotein binding
- RNase_Ire1_like
- ankyrin repeats
Pathways
Biological processes and signaling networks where the Rnasel gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neonatal late-onset sepsis
- ovarian cancer
- fibrosis
- hyperplasia
- demyelination
- hereditary prostate cancer 1
- pulmonary emphysema
- susceptibility to prostate cancer
- multiple sclerosis
- familial prostate cancer
role in cell
- survival
- expression in
- phosphorylation in
- cell death
- apoptosis
- production in
- proliferation
- activation in
- growth
- accumulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- mitochondrial fraction
- Mitochondria
- cytosol
- mitochondrial matrix
- nuclear matrix
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnasel gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- defense response to virus
- positive regulation of glucose import
- regulation of mRNA stability
- RNA processing
- mRNA processing
- fat cell differentiation
- rRNA processing
- positive regulation of transcription from RNA polymerase II promoter
- protein phosphorylation
- negative regulation of viral genome replication
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- cytosol
- nuclear matrix
Molecular Function
What the gene product does at the molecular level
- ATP binding
- RNA binding
- protein binding
- metal ion binding
- ribonucleoprotein complex binding
- ribonuclease activity
- protein kinase activity
- rRNA binding
- endoribonuclease activity