Cdkn1c Gene Summary [Mouse]
Predicted to enable protein kinase inhibitor activity. Involved in negative regulation of phosphorylation. Acts upstream of or within several processes, including embryonic placenta morphogenesis; regulation of gene expression; and uterus development. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; extraembryonic component; genitourinary system; and sensory organ. Used to study Beckwith-Wiedemann syndrome and pre-eclampsia. Human ortholog(s) of this gene implicated in Beckwith-Wiedemann syndrome; IMAGe syndrome; and hyperinsulinism. Orthologous to human CDKN1C (cyclin dependent kinase inhibitor 1C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdkn1c |
| Official Name | cyclin-dependent kinase inhibitor 1C (P57) [Source:MGI Symbol;Acc:MGI:104564] |
| Ensembl ID | ENSMUSG00000037664 |
| Bio databases IDs | |
| Aliases | cyclin-dependent kinase inhibitor 1C (P57) |
| Synonyms | BWCR, BWS, CDK1C, CDKI, CDK INHIBITOR 1C, cyclin-dependent kinase inhibitor 1C, IMAGE, KIP2, p57, p57KIP2, p57(kip2), WBS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdkn1c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- QT domain
- PCNA binding domain
- 3-10 helix
- Cki domain
- protein kinase inhibitor activity
- alpha helix
- cdk phosphorylation site
- protein binding
- acidic domain
- proline rich domain
- cyclin-dependent kinase binding domain
- cyclin-CDK binding domain
- binding protein
- cyclin-binding domain
- Cyclin-dependent kinase inhibitor
Pathways
Biological processes and signaling networks where the Cdkn1c gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- thrombocytopenia
- psoriasis
- epithelial cancer
- epithelial neoplasia
- cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
phenotypes
- abnormal embryo size
- abnormal heart morphology
- abnormal kidney morphology
- abnormal testis morphology
- preweaning lethality complete penetrance
- small kidney
- abnormal abdominal wall morphology
- abnormal bone ossification
- abnormal brown adipose tissue morphology
- abnormal craniofacial bone morphology
- abnormal digestive system development
- abnormal digestive system morphology
- abnormal duodenum morphology
- abnormal endochondral bone ossification
- abnormal female reproductive system morphology
- abnormal fertility/fecundity
- abnormal gland morphology
- abnormal hard palate morphology
- abnormal humerus morphology
- abnormal ileum morphology
- abnormal interscapular fat pad morphology
- abnormal intestine morphology
- abnormal intramembranous bone ossification
- abnormal jejunum morphology
- abnormal kidney medulla development
- abnormal kidney papilla morphology
- abnormal lens development
- abnormal lens epithelium morphology
- abnormal limb bone morphology
- abnormal long bone epiphyseal plate morphology
- abnormal long bone epiphysis morphology
- abnormal long bone morphology
- abnormal male reproductive system morphology
- abnormal midbrain morphology
- abnormal placenta labyrinth morphology
- abnormal placenta morphology
- abnormal prostate gland development
- abnormal renal glomerulus morphology
- abnormal renal tubule morphology
- abnormal retina morphology
- abnormal rib morphology
- abnormal seminal vesicle development
- abnormal skeletal muscle morphology
- abnormal skeleton development
- abnormal soft palate morphology
- abnormal spleen white pulp morphology
- abnormal spongiotrophoblast layer morphology
- abnormal suckling behavior
- abnormal testis development
- abnormal trophoblast giant cell morphology
- abnormal uterus development
- abnormal vertebrae morphology
- absent gastric milk in neonates
- absent jejunum
- absent ovarian follicles
- cataract
- cleft palate
- cleft secondary palate
- cortical renal glomerulopathies
- cyanosis
- decreased body size
- decreased body weight
- decreased brown adipose tissue amount
- decreased fetal size
- decreased length of long bones
- delayed bone ossification
- delayed endochondral bone ossification
- delayed sexual maturation
- dysphagia
- embryonic growth retardation
- enlarged adrenal glands
- enlarged placenta
- female infertility
- herniated abdominal wall
- hydrometra
- increased diameter of long bones
- increased lens epithelium apoptosis
- increased midbrain apoptosis
- increased placenta weight
- increased systemic arterial blood pressure
- increased systemic arterial systolic blood pressure
- increased urine protein level
- lethality throughout fetal growth and development incomplete penetrance
- meteorism
- neonatal lethality complete penetrance
- neonatal lethality incomplete penetrance
- no abnormal phenotype detected
- omphalocele
- palatal shelves fail to meet at midline
- paternal imprinting
- postnatal growth retardation
- postnatal lethality complete penetrance
- postnatal lethality incomplete penetrance
- respiratory distress
- short gestation period
- short limbs
- small inner medullary pyramid
- split sternum
- thrombocytopenia
- uterus atresia
- uterus atrophy
- vacuolated lens
- vagina atresia
role in cell
- apoptosis
- phosphorylation in
- binding in
- expression in
- proliferation
- quantity
- cell viability
- survival
- accumulation
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdkn1c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of epithelial cell proliferation
- negative regulation of mitotic cell cycle
- negative regulation of kinase activity
- negative regulation of cyclin-dependent protein kinase activity
- negative regulation of phosphorylation
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cyclin-dependent protein kinase inhibitor activity
- protein kinase inhibitor activity