MAP3K9 Gene Summary [Human]
Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K9 |
| Official Name | mitogen-activated protein kinase kinase kinase 9 [Source:HGNC Symbol;Acc:HGNC:6861] |
| Ensembl ID | ENSG00000006432 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 9 |
| Synonyms | E130314H24Rik, MEKK9, mitogen-activated protein kinase kinase kinase 9, MLK1, PRKE1, RGD1562149 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- JUN kinase kinase kinase
- protein binding
- Protein kinase domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- Protein Kinases, catalytic domain
- alcohol group acceptor phosphotransferase
- protein homodimerization
- Tyrosine kinase, catalytic domain
- Domain of unknown function (DUF4200)
Pathways
Biological processes and signaling networks where the MAP3K9 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- Reelin Signaling in Neurons
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- STAT3 Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-small cell lung cancer
- insomnia
- non-small cell lung carcinoma
- pervasive developmental disorder
- productive infection by HIV-1
role in cell
- apoptosis
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- positive regulation of apoptotic process
- apoptotic process
- protein autophosphorylation
- protein phosphorylation
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein homodimerization activity
- protein binding
- JUN kinase kinase kinase activity
- MAP kinase kinase activity
- protein serine/threonine kinase activity