MAP3K10 Gene Summary [Human]
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | MAP3K10 |
| Official Name | mitogen-activated protein kinase kinase kinase 10 [Source:HGNC Symbol;Acc:HGNC:6849] |
| Ensembl ID | ENSG00000130758 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase kinase kinase 10, MKN28 kinase, mixed lineage kinase 2, MKN28 derived nonreceptor_type serine/threonine kinase |
| Synonyms | LOC102552215, MEKK10, mitogen-activated protein kinase kinase kinase 10, MLK2, MST |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MAP3K10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTPase binding domain
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- protein kinase
- Protein tyrosine and serine/threonine kinase
- clathrin box motif
- transcription co-repressor
- JUN kinase kinase kinase
- transcription factor binding
- leucine zipper domain
- protein binding
- Protein kinase domain
- Src Homology 3 domain superfamily
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- protein homodimerization
- basic domain
- Tyrosine kinase, catalytic domain
- Mob-binding domain found in the NDR/LATS family serine/threonine protein kinases
Pathways
Biological processes and signaling networks where the MAP3K10 gene in human plays a role, providing insight into its function and relevance in health or disease.
- B Cell Receptor Signaling
- Cardiac Hypertrophy Signaling
- CD27 Signaling in Lymphocytes
- G-Protein Coupled Receptor Signaling
- Germ Cell-Sertoli Cell Junction Signaling
- GNRH Signaling
- HGF Signaling
- Huntington's Disease Signaling
- Natural Killer Cell Signaling
- NGF Signaling
- PKCθ Signaling in T Lymphocytes
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- RANK Signaling in Osteoclasts
- Reelin Signaling in Neurons
- SAPK/JNK Signaling
- Sertoli Cell-Sertoli Cell Junction Signaling
- Signaling by Rho Family GTPases
- STAT3 Pathway
- Xenobiotic Metabolism Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
role in cell
- apoptosis
- phosphorylation in
- inhibition in
- cell death
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MAP3K10 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of JUN kinase activity
- signal transduction
- smoothened signaling pathway
- protein autophosphorylation
- JNK cascade
- negative regulation of sequence-specific DNA binding transcription factor activity
- negative regulation of transcription, DNA-dependent
- positive regulation of JNK cascade
- positive regulation of apoptotic process
- apoptotic process
- peptidyl-serine phosphorylation
- peptidyl-threonine phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- protein homodimerization activity
- transcription corepressor activity
- JUN kinase kinase kinase activity
- protein kinase activity
- protein serine/threonine kinase activity
- bHLH transcription factor binding